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Monitor Carefully (two)pentobarbital will lower the extent or result of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Sturdy CYP3A4 inducers could minimize suvorexant efficacy; if enhanced suvorexant dose required, usually do not exceed twenty mg/daypentobarbital will reduce the extent or outcome of ibu